Chemicals and Drugs

Everolimus

A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT.

Chemical Identity

Chemical Information

Molecular Formula
C53H83NO14
Molecular Weight
958.2 g/mol
CAS Registry No.
159351-69-6
IUPAC Name
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
InChIKey
HKVAMNSJSFKALM-GKUWKFKPSA-N
SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC
MeSH Unique ID
D000068338
Source
PubChem CID 6442177

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

10 entry terms
  • 40-O-(2-hydroxyethyl)-rapamycin
  • SDZ RAD
  • SDZ-RAD
  • RAD, SDZ
  • Afinitor
  • Certican
  • RAD 001
  • RAD001
  • Zortress
  • 001, RAD

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (1997)

MeSH Hierarchy

Tree Number

  1. D02w.540w.505w.760w.500w

AMA Style

References

  1. National Library of Medicine. Everolimus. Medical Subject Headings (MeSH). 2026. Unique ID D000068338. http://id.nlm.nih.gov/mesh/2026/D000068338
  2. Everolimus. In: Wikipedia. https://en.wikipedia.org/wiki/Everolimus
  3. Everolimus. In: Wikidata. https://www.wikidata.org/wiki/Q421052
  4. Everolimus. In: PubChem Compound. CID 6442177. https://pubchem.ncbi.nlm.nih.gov/compound/6442177