Chemicals and Drugs

Glycine Receptors

Cell surface receptors that bind GLYCINE with high affinity and trigger intracellular changes which influence the behavior of cells. Glycine receptors in the CENTRAL NERVOUS SYSTEM have an intrinsic chloride channel. GlyA receptor is sensitive to STRYCHNINE and localized in the post-synaptic membrane of inhibitory glycinergic neurons. GlyB receptor is insensitive to strychnine and associated with the excitatory NMDA receptor.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cell surface receptors that bind GLYCINE with high affinity and trigger intracellular changes which influence the behavior of cells. Glycine receptors in the CENTRAL NERVOUS SYSTEM have an intrinsic chloride channel. GlyA receptor is sensitive to STRYCHNINE and localized in the post-synaptic membrane of inhibitory glycinergic neurons. GlyB receptor is insensitive to strychnine and associated with the excitatory NMDA receptor.

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Synonyms

23 entry terms
  • Glycine Receptor
  • Receptors, Glycine
  • Receptor, Glycine
  • Excitatory Glycine Receptors
  • GlyA Receptors
  • GlyB Receptors
  • Glycine A Receptors
  • Glycine B Receptors
  • Glycine Receptor alpha1
  • Inhibitory Glycine Receptor
  • SIG Receptor
  • Strychnine-Insensitive Glycine Receptor
  • Strychnine-Sensitive Glycine Receptor
  • Glycine Receptor, Inhibitory
  • Glycine Receptor, Strychnine-Insensitive
  • Glycine Receptor, Strychnine-Sensitive
  • Receptor, Inhibitory Glycine
  • Receptor, SIG
  • Receptor, Strychnine-Insensitive Glycine
  • Receptor, Strychnine-Sensitive Glycine
  • Receptors, GlyB
  • Strychnine Insensitive Glycine Receptor
  • Strychnine Sensitive Glycine Receptor

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

1994; was GLYCINE RECEPTOR (NM) 1981-1993; for GLYCINE RECEPTOR ALPHA1 was under RECEPTORS, GLYCINE 1995-2020; for GLYCINE RECEPTOR ALPHA1 was under RECEPTORS, GLYCINE 1997-2020

MeSH Record

Previous Indexing

  • Receptors, Cell Surface (1981-1984)
  • Receptors, Neurotransmitter (1985-1993)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.175w.781w
  2. D12.776w.157w.530w.400w.400w.100w.200w
  3. D12.776w.543w.550w.450w.175w.781w
  4. D12.776w.543w.550w.450w.500w.100w.200w
  5. D12.776w.543w.585w.400w.175w.781w
  6. D12.776w.543w.585w.400w.500w.100w.200w
  7. D12.776w.543w.750w.130w.625w
  8. D12.776w.543w.750w.720w.200.470w

AMA Style

References

  1. National Library of Medicine. Glycine Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D018009. http://id.nlm.nih.gov/mesh/2026/D018009
  2. Glycine Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Glycine_receptor
  3. Glycine Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q426887