Chemicals and Drugs

Guanine Nucleotide-Releasing Factor 2

A 145-kDa guanine nucleotide exchange factor that is specific for rap1 and ras GTP-BINDING PROTEINS. It associates with SH3 domains of the crk family of signaling proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 145-kDa guanine nucleotide exchange factor that is specific for rap1 and ras GTP-BINDING PROTEINS. It associates with SH3 domains of the crk family of signaling proteins.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

8 entry terms
  • C3G Protein
  • GRF-2
  • GRF2
  • GRF2 Protein
  • GRF2 Protein, Mammalian
  • Guanine Nucleotide Exchange Factor C3G
  • RAP1GRF1
  • GRF 2

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; use GUANINE NUCLEOTIDE EXCHANGE FACTORS (NM) 1997-1999

MeSH Record

Previous Indexing

  • Proteins (1997-1999)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.325w.300w.300
  2. D12.776w.476.325w.300w.300

AMA Style

References

  1. National Library of Medicine. Guanine Nucleotide-Releasing Factor 2. Medical Subject Headings (MeSH). 2026. Unique ID D020735. http://id.nlm.nih.gov/mesh/2026/D020735
  2. Guanine Nucleotide-Releasing Factor 2. In: Wikidata. https://www.wikidata.org/wiki/Q76448800