Structured Summary
Abstract
A method of detecting gene mutation by mixing PCR-amplified mutant and wild-type DNA followed by denaturation and reannealing. The resultant products are resolved by gel electrophoresis, with single base substitutions detectable under optimal electrophoretic conditions and gel formulations. Large base pair mismatches may also be analyzed by using electron microscopy to visualize heteroduplex regions.
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Synonyms
3 entry terms
- Analyses, Heteroduplex
- Analysis, Heteroduplex
- Heteroduplex Analyses
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Aspects Covered
10 allowable subheadings
Indexed with the subheadings classification, economics, ethics, history, instrumentation, methods, standards, statistics & numerical data, trends, veterinary.
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History Note
1999
MeSH Record
Previous Indexing
- Nucleic Acid Heteroduplexes (1980-1998)
- Nucleic Acid Hybridization (1973-1979)
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AMA Style
References
- National Library of Medicine. Heteroduplex Analysis. Medical Subject Headings (MeSH). 2026. Unique ID D020180. http://id.nlm.nih.gov/mesh/2026/D020180
- Heteroduplex Analysis. In: Wikipedia. https://en.wikipedia.org/wiki/Heteroduplex_analysis
- Heteroduplex Analysis. In: Wikidata. https://www.wikidata.org/wiki/Q73522674