Chemicals and Drugs

Hyaluronan Synthases

Membrane-associated glucuronosyltransferases that catalyze the reaction of UDP-N-acetyl-D-glucosamine and UDP-D-glucuronate to produce HYALURONAN. HYALURONAN SYNTHASE 2 (HAS2) is essential for embryogenesis and its expression by tumor cells is associated with metastasis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Membrane-associated glucuronosyltransferases that catalyze the reaction of UDP-N-acetyl-D-glucosamine and UDP-D-glucuronate to produce HYALURONAN. HYALURONAN SYNTHASE 2 (HAS2) is essential for embryogenesis and its expression by tumor cells is associated with metastasis.

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MeSH Record

Synonyms

23 entry terms
  • Hyaluronan Synthase
  • Hyaluronan Synthetase
  • Hyaluronate Synthase
  • Hyaluronate Synthetase
  • Hyaluronic Acid Synthetase
  • Synthase, Hyaluronan
  • Synthase, Hyaluronate
  • Synthases, Hyaluronan
  • Synthetase, Hyaluronan
  • Synthetase, Hyaluronate
  • Synthetase, Hyaluronic Acid
  • HAS1 Protein
  • HAS2 Protein
  • HAS3 Protein
  • Hyaluronan Synthase 1
  • Hyaluronan Synthase 2
  • Hyaluronan Synthase 3
  • hasA Enzyme
  • 3, Hyaluronan Synthase
  • Protein, HAS3
  • Synthase 1, Hyaluronan
  • Synthase 2, Hyaluronan
  • Synthase 3, Hyaluronan

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1976); was HYALURONAN SYNTHASE 1976-2017

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References

  1. National Library of Medicine. Hyaluronan Synthases. Medical Subject Headings (MeSH). 2026. Unique ID D000076002. http://id.nlm.nih.gov/mesh/2026/D000076002
  2. Hyaluronan Synthases. In: Wikipedia. https://en.wikipedia.org/wiki/Hyaluronan_synthase
  3. Hyaluronan Synthases. In: Wikidata. https://www.wikidata.org/wiki/Q5952725