Chemicals and Drugs

Insulin Receptor

A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

10 entry terms
  • Insulin Receptor Protein-Tyrosine Kinase
  • Insulin-Dependent Tyrosine Protein Kinase
  • Receptor, Insulin
  • Receptors, Insulin
  • Insulin Receptor Protein Tyrosine Kinase
  • Insulin Receptors
  • Insulin Receptor alpha Chain
  • Insulin Receptor alpha Subunit
  • Insulin Receptor beta Chain
  • Insulin Receptor beta Subunit

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000(1977); for INSULIN RECEPTOR PROTEIN-TYROSINE KINASE use RECEPTOR, INSULIN (NM) 1983-1993

MeSH Record

Previous Indexing

  • Insulin (1966-1976)
  • Receptors, Drug (1968-1976)
  • Receptors, Endogenous Substances (1973-1976)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.200w
  2. D12.776w.476.568w.400w.200w
  3. D12.776w.543w.750w.630w.484w
  4. D12.776w.543w.750w.750w.580.300w

MeSH Record

NLM Classification

WK 802

AMA Style

References

  1. National Library of Medicine. Insulin Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D011972. http://id.nlm.nih.gov/mesh/2026/D011972
  2. Insulin Receptor. In: Wikipedia. https://en.wikipedia.org/wiki/Insulin_receptor
  3. Insulin Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q422579