Chemicals and Drugs

Integrin alpha4beta1

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

15 entry terms
  • CD49d-CD29
  • Integrin Heterodimer alpha4beta1
  • Integrin alpha(4)beta(1)
  • VLA-4
  • Very Late Activation Antigen-4
  • Very Late Antigen-4
  • alpha4beta1 Integrin
  • Antigen-4, Very Late
  • Heterodimer alpha4beta1, Integrin
  • Integrin, alpha4beta1
  • Late Antigen-4, Very
  • Very Late Activation Antigen 4
  • Very Late Antigen 4
  • alpha4beta1, Integrin
  • alpha4beta1, Integrin Heterodimer

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2003 (1991)

MeSH Record

Previous Indexing

  • Integrins (1991-2002)
  • Receptors, Lymphocyte Homing (1991-2002)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.200w.625w.347w
  2. D12.776w.395w.550w.200w.625w.347w
  3. D12.776w.543w.550w.200w.625w.347w
  4. D12.776w.543w.750w.705w.408w.530.500w
  5. D12.776w.543w.750w.705w.408w.850.299w
  6. D12.776w.543w.750w.705w.877w.347w
  7. D23.050w.301.350w.625w.347w

AMA Style

References

  1. National Library of Medicine. Integrin alpha4beta1. Medical Subject Headings (MeSH). 2026. Unique ID D039041. http://id.nlm.nih.gov/mesh/2026/D039041
  2. Integrin alpha4beta1. In: Wikipedia. https://en.wikipedia.org/wiki/VLA-4
  3. Integrin alpha4beta1. In: Wikidata. https://www.wikidata.org/wiki/Q50257813