Chemicals and Drugs

Integrins

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.

MeSH Record

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Synonyms

1 entry terms
  • Integrin

MeSH Record

Aspects Covered

20 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

Indexing Annotation

prefer specifics

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Glycoproteins (1966-1987)
  • Membrane Glycoproteins (1988-1989)
  • Receptors, Endogenous Substances (1973-1989)
  • Receptors, Immunologic (1980-1989)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.705w.408w

AMA Style

References

  1. National Library of Medicine. Integrins. Medical Subject Headings (MeSH). 2026. Unique ID D016023. http://id.nlm.nih.gov/mesh/2026/D016023
  2. Integrins. In: Wikipedia. https://en.wikipedia.org/wiki/Integrin
  3. Integrins. In: Wikidata. https://www.wikidata.org/wiki/Q409715