Chemicals and Drugs

Leukocyte-Adhesion Receptors

Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.

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Synonyms

12 entry terms
  • Leu-CAM Receptor Family
  • Leukocyte-Adhesion Receptor
  • Leukocyte-Adhesion Receptor Family
  • Receptors, Leukocyte-Adhesion
  • Family, Leu-CAM Receptor
  • Leu CAM Receptor Family
  • Leukocyte Adhesion Receptor
  • Leukocyte Adhesion Receptor Family
  • Leukocyte Adhesion Receptors
  • Receptor Family, Leu-CAM
  • Receptor, Leukocyte-Adhesion
  • Receptors, Leukocyte Adhesion

MeSH Record

Aspects Covered

18 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

90

MeSH Record

Previous Indexing

  • Antigens (1966-1987)
  • Antigens, Differentiation (1988-1989)
  • Receptors, Cell Surface (1973-1989)
  • Receptors, Immunologic (1980-1989)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.705w.408w.600

AMA Style

References

  1. National Library of Medicine. Leukocyte-Adhesion Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D016028. http://id.nlm.nih.gov/mesh/2026/D016028
  2. Leukocyte-Adhesion Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q76692709