Structured Summary
Abstract
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
MeSH Record
Classification
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MeSH Record
Synonyms
4 entry terms
- Integrin alpha Subunits
- alpha Integrins
- Integrins, alpha
- alpha Chains, Integrin
MeSH Record
Aspects Covered
19 allowable subheadings
Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.
MeSH Record
History Note
2003
MeSH Record
Previous Indexing
- Integrins (1966-2002)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Integrin alpha Chains. Medical Subject Headings (MeSH). 2026. Unique ID D039001. http://id.nlm.nih.gov/mesh/2026/D039001
- Integrin alpha Chains. In: Wikipedia. https://en.wikipedia.org/wiki/CD11
- Integrin alpha Chains. In: Wikidata. https://www.wikidata.org/wiki/Q24780761