Structured Summary
Abstract
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
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Synonyms
13 entry terms
- A9 Antigen
- Integrin alpha(6),beta(4)
- Laminin-5 Receptor (alpha6beta4 Integrin)
- TSP-180
- Tumor Specific Protein-180 Complex
- alpha(6)beta(4) Epithelial Integrin
- alpha(6)beta(4) Integrin
- alpha6 beta4 Integrin
- Antigen, A9
- Integrin, alpha6 beta4
- Tumor Specific Protein 180 Complex
- alpha6beta4, Integrin
- beta4 Integrin, alpha6
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Aspects Covered
19 allowable subheadings
Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.
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History Note
2003; use INTEGRIN ALPHA6BETA4 (NM) 1988-2002
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Previous Indexing
- Antigens, Surface (1988-2002)
- Integrins (1988-2002)
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Tree Numbers
AMA Style
References
- National Library of Medicine. Integrin alpha6beta4. Medical Subject Headings (MeSH). 2026. Unique ID D039161. http://id.nlm.nih.gov/mesh/2026/D039161
- Integrin alpha6beta4. In: Wikidata. https://www.wikidata.org/wiki/Q50251711