Chemicals and Drugs

Interleukin-1

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

MeSH Record

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MeSH Record

Synonyms

9 entry terms
  • Epidermal Cell Derived Thymocyte-Activating Factor
  • IL-1
  • Interleukin I
  • Lymphocyte-Activating Factor
  • Macrophage Cell Factor
  • T Helper Factor
  • Epidermal Cell Derived Thymocyte Activating Factor
  • Interleukin 1
  • Lymphocyte Activating Factor

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1990(1983)

MeSH Record

Previous Indexing

  • Lymphocyte Transformation (1972-1982)
  • Lymphocytes (1966-1971)
  • Lymphokines (1974-1982)
  • Macrophages (1966-1982)
  • Toxins (1966-1973)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.374w.465w.010w
  2. D12.644w.276.374w.500w.400w
  3. D12.776w.467.374w.465w.010w
  4. D12.776w.467.374w.500w.400w
  5. D23.529.374w.465w.131w
  6. D23.529.374w.500w.400w

AMA Style

References

  1. National Library of Medicine. Interleukin-1. Medical Subject Headings (MeSH). 2026. Unique ID D007375. http://id.nlm.nih.gov/mesh/2026/D007375
  2. Interleukin-1. In: Wikipedia. https://en.wikipedia.org/wiki/Interleukin-1_family
  3. Interleukin-1. In: Wikidata. https://www.wikidata.org/wiki/Q1706141