Chemicals and Drugs

Mitogen-Activated Protein Kinases

A superfamily of PROTEIN SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A superfamily of PROTEIN SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).

MeSH Record

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Synonyms

7 entry terms
  • Mitogen Activated Protein Kinase
  • Mitogen-Activated Protein Kinase
  • Kinase, Mitogen-Activated Protein
  • Kinases, Mitogen-Activated Protein
  • Mitogen Activated Protein Kinases
  • Protein Kinase, Mitogen-Activated
  • Protein Kinases, Mitogen-Activated

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; for EXTRACELLULAR SIGNAL-REGULATED KINASES use CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1994-1999

MeSH Record

Previous Indexing

  • Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1999)
  • Protein Kinases (1989-1999)
  • Protein-Serine-Threonine Kinases (1993-1999)
  • Protein-Tyrosine Kinase (1989-1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.567w
  2. D12.776w.476.563w.567w

AMA Style

References

  1. National Library of Medicine. Mitogen-Activated Protein Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D020928. http://id.nlm.nih.gov/mesh/2026/D020928
  2. Mitogen-Activated Protein Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase
  3. Mitogen-Activated Protein Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q899651