Chemicals and Drugs

JNK Mitogen-Activated Protein Kinases

A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

15 entry terms
  • c-jun Amino-Terminal Kinase
  • c-jun N-Terminal Kinase
  • jun N-Terminal Kinase
  • jun-NH2-Terminal Kinase
  • jun-NH2-Terminal Kinases
  • Amino-Terminal Kinase, c-jun
  • JNK Mitogen Activated Protein Kinases
  • Kinase, jun N-Terminal
  • N-Terminal Kinase, c-jun
  • N-Terminal Kinase, jun
  • c jun Amino Terminal Kinase
  • c jun N Terminal Kinase
  • jun N Terminal Kinase
  • jun NH2 Terminal Kinase
  • jun NH2 Terminal Kinases

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

note specifics

MeSH Record

History Note

2005

MeSH Record

Previous Indexing

  • Ca(2+)-Calmodulin Dependent Protein Kinase (1995-1999)
  • Mitogen-Activated Protein Kinases (2000-2004)
  • Protein-Serine-Threonine Kinases (1993-1994)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.567w.374w
  2. D12.776w.476.563w.567w.374w

AMA Style

References

  1. National Library of Medicine. JNK Mitogen-Activated Protein Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D048031. http://id.nlm.nih.gov/mesh/2026/D048031
  2. JNK Mitogen-Activated Protein Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases
  3. JNK Mitogen-Activated Protein Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q24774703