Chemicals and Drugs

Monomeric GTP-Binding Proteins

A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety of intracellular processes. The GTP bound form of the protein is active and limited by its inherent GTPase activity, which is controlled by an array of GTPase activators, GDP dissociation inhibitors, and guanine nucleotide exchange factors. This enzyme was formerly listed as EC 3.6.1.47

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety of intracellular processes. The GTP bound form of the protein is active and limited by its inherent GTPase activity, which is controlled by an array of GTPase activators, GDP dissociation inhibitors, and guanine nucleotide exchange factors. This enzyme was formerly listed as EC 3.6.1.47

MeSH Record

Classification

Broader headings

Narrower headings

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MeSH Record

Synonyms

37 entry terms
  • G-Proteins, Monomeric
  • GTP-Binding Proteins, Monomeric
  • Monomeric G-Protein
  • Monomeric G-Proteins
  • Small G-Protein
  • Small G-Proteins
  • Small GTPase
  • Small GTPases
  • G Proteins, Monomeric
  • G-Protein, Monomeric
  • G-Protein, Small
  • G-Proteins, Small
  • GTP Binding Proteins, Monomeric
  • GTPase, Small
  • GTPases, Small
  • Monomeric G Protein
  • Monomeric G Proteins
  • Monomeric GTP Binding Proteins
  • Small G Protein
  • Small G Proteins
  • ras-Related G-Proteins
  • ras-Related GTP-Binding Protein
  • ras-Related GTP-Binding Proteins
  • ras-Related GTPase
  • ras-Related GTPases
  • G-Proteins, ras-Related
  • GTP-Binding Protein, ras-Related
  • GTP-Binding Proteins, ras-Related
  • GTPase, ras-Related
  • GTPases, ras-Related
  • Protein, ras-Related GTP-Binding
  • Proteins, ras-Related GTP-Binding
  • ras Related G Proteins
  • ras Related GTP Binding Protein
  • ras Related GTP Binding Proteins
  • ras Related GTPase
  • ras Related GTPases

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000

MeSH Record

Previous Indexing

  • GTP-Binding Proteins (1997-1999)
  • Heterotrimeric GTP-Binding Proteins (1985-1996)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.330.300.400
  2. D12.776w.157w.325.515
  3. D12.776w.476.338.400

AMA Style

References

  1. National Library of Medicine. Monomeric GTP-Binding Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D020559. http://id.nlm.nih.gov/mesh/2026/D020559
  2. Monomeric GTP-Binding Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q78190013