Chemicals and Drugs

Proto-Oncogene Proteins c-rel

Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause tumorigenesis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause tumorigenesis.

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Synonyms

25 entry terms
  • Proto-Oncogene Products c-rel
  • Proto-Oncogene Protein c-rel
  • Proto-Oncogene Proteins rel
  • c-rel Protein
  • c-rel Proteins
  • p68 c-rel
  • p68(c-rel)
  • rel Proto-Oncogene Product p68
  • rel Proto-Oncogene Proteins
  • Protein, c-rel
  • Proteins, c-rel
  • Proto Oncogene Products c rel
  • Proto Oncogene Protein c rel
  • Proto Oncogene Proteins c rel
  • Proto Oncogene Proteins rel
  • Proto-Oncogene Proteins, rel
  • c rel Protein
  • c rel Proteins
  • c-rel, Proto-Oncogene Products
  • c-rel, Proto-Oncogene Protein
  • c-rel, Proto-Oncogene Proteins
  • c-rel, p68
  • p68 c rel
  • rel Proto Oncogene Product p68
  • rel Proto Oncogene Proteins

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000; use PROTO-ONCOGENE PROTEINS C-REL (NM) 1988-1999

MeSH Record

Previous Indexing

  • Proto-Oncogene Proteins (1988-1999)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.682
  2. D12.776w.624.664.700.192
  3. D12.776w.660w.767
  4. D12.776w.930w.730

AMA Style

References

  1. National Library of Medicine. Proto-Oncogene Proteins c-rel. Medical Subject Headings (MeSH). 2026. Unique ID D020569. http://id.nlm.nih.gov/mesh/2026/D020569
  2. Proto-Oncogene Proteins c-rel. In: Wikidata. https://www.wikidata.org/wiki/Q24785631