Structured Summary
Abstract
One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Chemical Identity
Chemical Information
- Molecular Formula
- C26H29NO
- Molecular Weight
- 371.5 g/mol
- CAS Registry No.
- 10540-29-1
- IUPAC Name
- 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
- InChIKey
- NKANXQFJJICGDU-QPLCGJKRSA-N
- SMILES
- CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3
- MeSH Unique ID
- D013629
- Source
- PubChem CID 2733526
MeSH Record
Classification
Broader headings
Narrower headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
16 entry terms
- ICI-46,474
- ICI-46474
- ICI-47699
- Nolvadex
- Novaldex
- Soltamox
- Tamoxifen Citrate
- Tomaxithen
- Zitazonium
- Citrate, Tamoxifen
- ICI 46,474
- ICI 46474
- ICI 47699
- ICI46,474
- ICI46474
- ICI47699
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
78(75); was see under STILBENES 1975-77
MeSH Record
Previous Indexing
- Dimethylamines (1973-1974)
- Phenyl Ethers (1974)
- Stilbenes (1966-1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Tamoxifen. Medical Subject Headings (MeSH). 2026. Unique ID D013629. http://id.nlm.nih.gov/mesh/2026/D013629
- Tamoxifen. In: Wikipedia. https://en.wikipedia.org/wiki/Tamoxifen
- Tamoxifen. In: Wikidata. https://www.wikidata.org/wiki/Q412178
- Tamoxifen. In: PubChem Compound. CID 2733526. https://pubchem.ncbi.nlm.nih.gov/compound/2733526