Chemicals and Drugs

Complementarity Determining Regions

Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).

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Synonyms

25 entry terms
  • Complementarity Determining Region
  • Complementarity-Determining Region
  • Hypervariable Region, Immunoglobulin
  • Hypervariable Regions, Immunoglobulin
  • Complementarity-Determining Regions
  • Immunoglobulin Hypervariable Region
  • Immunoglobulin Hypervariable Regions
  • Region, Complementarity Determining
  • Region, Immunoglobulin Hypervariable
  • Regions, Complementarity Determining
  • Regions, Complementarity-Determining
  • Regions, Immunoglobulin Hypervariable
  • Complementarity Determining Region 1
  • Complementarity Determining Region 2
  • Complementarity Determining Region 3
  • Complementarity Determining Region I
  • Complementarity Determining Region II
  • Complementarity Determining Region III
  • Complementarity-Determining Region 3
  • Third Complementarity-Determining Region
  • Complementarity-Determining Region 3s
  • Complementarity-Determining Region, Third
  • Complementarity-Determining Regions, Third
  • Third Complementarity Determining Region
  • Third Complementarity-Determining Regions

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2001; for COMPLEMENTARITY DETERMINING REGION and HYPERVARIABLE REGION use IMMUNOGLOBULIN VARIABLE REGION 1988-2000

MeSH Record

Previous Indexing

  • Immunoglobulin Variable Region (1982-2000)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.541.500.650w.500.180w
  2. D12.776w.124w.486.485.680.650w.500.180w
  3. D12.776w.124w.486.485.797.180w
  4. D12.776w.124w.790.651.680.650w.500.180w
  5. D12.776w.124w.790.651.797.180w
  6. D12.776w.377w.715.548.680.650w.500.180w
  7. D12.776w.377w.715.548.797.180w
  8. D12.776w.543w.750w.705w.816.824w.300w
  9. G02.111.570.060w.425.160w

AMA Style

References

  1. National Library of Medicine. Complementarity Determining Regions. Medical Subject Headings (MeSH). 2026. Unique ID D022801. http://id.nlm.nih.gov/mesh/2026/D022801
  2. Complementarity Determining Regions. In: Wikipedia. https://en.wikipedia.org/wiki/Complementarity-determining_region
  3. Complementarity Determining Regions. In: Wikidata. https://www.wikidata.org/wiki/Q3826179