Structured Summary
Abstract
A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
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Classification
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MeSH Record
Synonyms
4 entry terms
- F-Box and WD-40 Domain-Containing Protein 7
- FBXW7 Protein
- F Box WD Repeat Containing Protein 7
- F Box and WD 40 Domain Containing Protein 7
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Cell Cycle Proteins (2006-2017)
- F-Box Proteins (2006-2017)
- Ubiquitin-Protein Ligases (2006-2017)
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AMA Style
References
- National Library of Medicine. F-Box-WD Repeat-Containing Protein 7. Medical Subject Headings (MeSH). 2026. Unique ID D000073979. http://id.nlm.nih.gov/mesh/2026/D000073979
- F-Box-WD Repeat-Containing Protein 7. In: Wikidata. https://www.wikidata.org/wiki/Q21113973