Chemicals and Drugs

N-Methyl-D-Aspartate Receptors

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

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MeSH Record

Synonyms

27 entry terms
  • N-Methyl-D-Aspartate Receptor
  • N-Methylaspartate Receptors
  • NMDA Receptor
  • NMDA Receptor-Ionophore Complex
  • NMDA Receptors
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, N-Methylaspartate
  • Receptors, NMDA
  • N Methyl D Aspartate Receptor
  • N Methyl D Aspartate Receptors
  • N Methylaspartate Receptors
  • NMDA Receptor Ionophore Complex
  • Receptor, N-Methyl-D-Aspartate
  • Receptor, NMDA
  • Receptors, N Methyl D Aspartate
  • Receptors, N Methylaspartate
  • GLUN2A Receptor
  • Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2A
  • Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate-Associated Protein 1
  • N-Methyl D-Aspartate Receptor Subtype 2A
  • NMDA Receptor 2A
  • NMDA Receptor A1
  • NMDAR1
  • NMDAR2A Protein
  • NMDARA1 Protein
  • Receptor 2A, NMDA
  • Receptor A1, NMDA

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92

MeSH Record

Previous Indexing

  • Receptors, Cell Surface (1973-1984)
  • Receptors, Neurotransmitter (1985-1990)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.400w.500w.500w
  2. D12.776w.543w.550w.450w.500w.200w.500w
  3. D12.776w.543w.585w.400w.500w.200w.500w
  4. D12.776w.543w.750w.720w.200.450w.400w.500w

AMA Style

References

  1. National Library of Medicine. N-Methyl-D-Aspartate Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D016194. http://id.nlm.nih.gov/mesh/2026/D016194
  2. N-Methyl-D-Aspartate Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/NMDA_receptor
  3. N-Methyl-D-Aspartate Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q414896