Chemicals and Drugs

Digoxin

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)

Chemical Identity

Chemical Information

Molecular Formula
C41H64O14
Molecular Weight
780.9 g/mol
CAS Registry No.
20830-75-5
IUPAC Name
3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
InChIKey
LTMHDMANZUZIPE-PUGKRICDSA-N
SMILES
C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O
MeSH Unique ID
D004077
Source
PubChem CID 2724385

MeSH Record

Classification

Broader headings

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

18 entry terms
  • Digacin
  • Digitek
  • Digoregen
  • Digoxina Boehringer
  • Digoxine Nativelle
  • Dilanacin
  • Hemigoxine Nativelle
  • Lanacordin
  • Lanicor
  • Lanoxicaps
  • Lanoxin
  • Lanoxin-PG
  • Lenoxin
  • Mapluxin
  • Boehringer, Digoxina
  • Lanoxin PG
  • Nativelle, Digoxine
  • Nativelle, Hemigoxine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not confuse with DIGITOXIN

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.155.580w.130.500.436w
  2. D04w.210.500w.155.580w.130.688w
  3. D09w.408w.180w.261.436w

AMA Style

References

  1. National Library of Medicine. Digoxin. Medical Subject Headings (MeSH). 2026. Unique ID D004077. http://id.nlm.nih.gov/mesh/2026/D004077
  2. Digoxin. In: Wikipedia. https://en.wikipedia.org/wiki/Digoxin
  3. Digoxin. In: Wikidata. https://www.wikidata.org/wiki/Q422222
  4. Digoxin. In: PubChem Compound. CID 2724385. https://pubchem.ncbi.nlm.nih.gov/compound/2724385